Samdin-5 – S (-) Amlodipine Besylate Tablets IP 5 mg – 1 × 10 Tablets

Samdin-5 Tablets provide a high-quality, modern antihypertensive therapy precisely engineered for the comprehensive management of essential hypertension and chronic stable angina in adult patients. By utilizing the isolated S (-) enantiomer rather than standard racemic amlodipine mixtures, this formulation delivers equivalent therapeutic blood pressure lowering at half the standard dose configuration of traditional amlodipine (10mg). This targeted molecular design maximizes clinical performance across arterial pathways while substantially reducing the risk of drug-induced peripheral edema (fluid accumulation in ankles and feet).

S (-) Amlodipine operates as a highly selective dihydropyridine calcium channel blocker. It binds specifically to L-type calcium channels across vascular smooth muscle cells, inhibiting the inward influx of extracellular calcium ions during cell depolarization. This blockade prevents muscle fiber contraction, promoting widespread peripheral and coronary vasodilation. By decreasing systemic peripheral vascular resistance, Samdin-5 smoothly scales down systolic and diastolic arterial pressures without inducing reflex tachycardia. In anginal conditions, it widens large coronary arteries and arterioles, improving baseline oxygen delivery to ischemic myocardial tissues and protecting structural heart systems during daily activities.

Key Benefits

• Chirally Pure Antihypertensive: Isolates the active S (-) enantiomer to achieve precise blood pressure regulation at an optimized therapeutic dose.

• Minimized Ankle Swelling: Lower dose layout drastically reduces the occurrence of peripheral edema compared to standard racemic amlodipine options.

• Stable 24-Hour Vascular Safety: Maintains balanced, long-acting blood pressure control through the night and early morning hours with a single dose.

• Protects Target Organs: Sustained microvascular control safeguards the kidneys, eyes, and myocardial walls from progressive hypertensive injury.

• Trusted Quality: Manufactured under the rigid quality benchmarks of Daxia Healthcare to guarantee accurate dosing uniformity.

Directions for Use

• Take exactly as directed by your physician or cardiologist.

• Swallow the tablet whole with a full glass of water. Do not crush, break, or chew it.

• Samdin-5 can be taken with or without food. * Try to take your dose at the exact same time every single day (morning or evening) to maintain uniform therapeutic blood concentrations.

Safety & Precautions

• Do not modify your dose or stop taking this medication suddenly. Abruptly halting antihypertensive therapy can cause a dangerous rebound spike in blood pressure levels or trigger acute chest pain profiles.

• May cause mild initial dizziness, lightheadedness, or flushing during the first few days of starting therapy. Rise slowly from sitting or lying positions, and avoid driving until you know how the medicine affects your motor coordination.

• Contraindicated during pregnancy and breastfeeding: Inform your specialist immediately if pregnancy is planned, suspected, or detected so that an alternative cardiovascular care timeline can be mapped.

• Use with caution if you have an underlying history of severe liver impairment or aortic stenosis. Periodic clinical monitoring is highly recommended.

• Keep out of reach of children.

Storage

• Store in a cool, dry place below 30°C.

• Protect from direct sunlight, excessive heat, and environmental room moisture.

• Keep the tablets safely stored inside their original protective packaging until the exact moment of consumption.